kenmochi laboratory

Publications - 業績一覧

Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N and Xu Y

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

Nucleic Acids Res., [Epub ahead of print] 2017

Ikeda F, Yoshida K, Toki T, Uechi T, Ishida S, Nakajima Y, Sasahara Y, Okuno Y, Kanezaki R, Terui K, Kamio T, Kobayashi A, Fujita T, Sato-Otsubo A, Shiraishi Y, Tanaka H, Chiba K, Muramatsu H, Kanno H, Ohga S, Ohara A, Kojima S, Kenmochi N, Miyano S, Ogawa S, Ito E.

Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.

Haematologica, 102:e93-e96. 2017

Ikeda T, Nakahara A, Nagano R, Utoyama M, Obara M, Moritake H, Uechi T, Mitsui J, Ishiura H, Yoshimura J, Doi K, Kenmochi N, Morishita S, Nishino I, Tsuji S, and Nunoi H

TBCD may be a causal gene in progressive neurodegenerative encephalopathy with atypical infantile spinal muscular atrophy.

J Hum Genet, 62:473-480. 2017

The RNAcentral Consortium

RNAcentral: a comprehensive database of non-coding RNA sequences.

Nucleic Acids Res., 45:D128-D134. 2017

上地珠代, 剣持直哉

第2章 動物実験の対象:ゼブラフィッシュ, 第3章 動物の飼育管理・基本的手技:魚類(ゼブラフィッシュ), 第4章 動物実験手法:ゼブラフィッシュを用いた疾患モデルの作製・解析

大・中・小動物実験プロトコル. 宮崎大学動物実験プロトコール編集委員会, 2016

剣持直哉, 吉浜麻生

第4章 snoRNA

ノンコーディングRNA−RNA分子の全体像を俯瞰する. 化学同人, 38-49, 2016

Patil P, Kibiryeva N, Uechi T, Marshall J, Artman M, O'Brien JE, Kenmochi N and Bittel DC

scaRNAs regulate splicing and vertebrate heart development.

Biochem. Biophys. Acta, 1852(8):1619-1629. 2015

Patil P, Uechi T, Kenmochi N

Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia

RNA Biology, 12(4):426-434. 2015

Wang R, Yoshida K, Toki T, Sawada T, Uechi T, Okuno Y, Sato-Otsubo A, Kudo K, Kamimaki I, Kanezaki R, Shiraishi Y, Chiba K, Tanaka H, Terui K, Sato T, Iribe Y, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Hara J, Goi K, Matsubara K, Koike K, Ishiguro A, Okamoto Y, Watanabe K, Kanno H, Kojima S, Miyano S, Kenmochi N, Ogawa S, Ito E.

Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.

Br J Haematol, 168(6):854-864. 2015

Yamamoto T, Yamamori K, Kenmochi N, Aikawa M

A detection method for snoRNA modification domain by fully indexable dictionary retrieving

Artif Life Robotics, 19:209-214. 2014

Yadav VG, Chakraborty A, Uechi T, Kenmochi N

Ribosomal protein deficiency causes Tp53-independent erythropoiesis failure in zebrafish

Int J Biochem Cell Biol, 49: 1-7. 2014

剣持直哉

リボソーム病ーリボソーム合成の異常と疾患ー

生化学:リボソームの機能調節と疾患. 85(10): 909-915. 2013

Yoshihama M, Nakao A, Kenmochi N

snOPY: a small nucleolar RNA orthological gene database

BMC Research Notes, 6: 426. 2013

山森一人,薛晨,岩切淳一,剣持直哉,吉原郁夫

構造モデルに基づく塩基配列からのboxC/D型snoRNA遺伝子検出法

情報処理学会論文誌:数理モデル化と応用 6(1): 79-89. 2013

Yamamori K, Matsuo T, Iwakiri J, Kenmochi N, Yoshihara I

A detection method for intronic snoRNA genes using extended- weight-updating SOM with appearance probability of bases

Artificial Life and Robotics, 17(3-4): 405-411. 2013

上地珠代, 剣持直哉

第1章リボソーム:リボソームタンパク質と翻訳制御

生体の科学:細胞の分子構造と機能−核以外の細胞小器官. 医学書院, 63(5): 362-363. 2012

Chakraborty A, Kenmochi N

Ribosomes and ribosomal proteins: More than just ‘housekeeping’

In: eLS 2012, John Wiley & Sons Ltd: Chichester http://www.els.net/ [DOI:10.1002/9780470015902.a0005055.pub2]

剣持直哉

第18章ゲノム:イントロン

進化学事典. 共立出版, 576-579. 2012

Iwakiri J, Tateishi H, Chakraborty A, Patil P, Kenmochi N

Dissecting the protein-RNA interface: the role of protein surface shapes and RNA secondary structures in protein-RNA recognition

Nucleic Acids Res, 40(8): 3299-3306. 2012

Higa-Nakamine S, Suzuki T, Uechi T, Chakraborty A, Nakajima Y, Nakamura M, Hirano N, Suzuki T, Kenmochi N

Loss of ribosomal RNA modification causes developmental defects in zebrafish

Nucleic Acids Res, 40(1): 391-398. 2012

剣持直哉

【RNA異常による疾患】リボソーム病とp53経路

医学のあゆみ:RNA医学・医療-あらたな診断・治療を拓く. 医歯薬出版株式会社, 238(5):476-480. 2011

Chakraborty A, Uechi T, Kenmochi N

Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway

WIREs RNA, 2(4): 507-522. 2011

Torihara H, Uechi T, Chakraborty A, Shinya M, Sakai N, Kenmochi N

Erythropoiesis failure due to RPS19 deficiency is independent of an activated p53 response in a zebrafish model of Diamond-Blackfan anaemia

Br J Haematol. 152(5): 648-654. 2011

Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K

The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function

J. Biol. Chem, 286(5): 3342-3350. 2011

剣持直哉

【4章】真核生物のsmall RNA

機能性RNAの分子生物学 The molecular biology of non-coding RNA. クバプロ, 111-150. 2010

比嘉三代美, 剣持直哉

ゼブラフィッシュにおけるRNA修飾の機能解析

蛋白質核酸酵素:mRNAプログラム. 54(16): 2092-2097. 2009

上地珠代, 剣持直哉

リボソーム病:翻訳装置のシステム障害

遺伝子医学MOOK:最新RNAと疾患研究. 15: 79-84. 2009

Chakraborty A, Uechi T, Higa S, Torihara H, Kenmochi N

Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response

PLoS ONE 4(1): e4152. 2009

Uechi T, Nakajima Y, Chakraborty A, Torihara H, Higa S, Kenmochi N

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia.

Hum Mol Genet. 17(20): 3204-3211. 2008

剣持直哉

イントロン内在型機能性RNA遺伝子の進化

生体の科学:特集 現代医学・生物学の仮説・学説. 59(5): 386-387. 2008

Marygold S, Roote J, Reuter G, Lambertsson A, Ashburner M, Millburn M, Harrison P, Yu Z, Kenmochi N, Kaufman TC, Leevers SJ, Cook KR.

The ribosomal protein genes and Minute loci of Drosophila melanogaster.

Genome Biol. 8: R216. 2007

Nguyen HD, Yoshihama M, Kenmochi N.

The evolution of spliceosomal introns in alveolates.

Mol Biol Evol. 24(5): 1093-1096. 2007

Nguyen HD, Yoshihara I, Yamamori K, Yasunaga M.

Implementation of an effective hybrid GA for large-scale traveling salesman problems.

IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics 37(1): 92-99. 2007

Yoshihama M, Nguyen HD, Kenmochi N.

Intron dynamics in ribosomal protein genes.

PLoS ONE 2(1): e141. 2007

Uechi T, Nakajima Y, Nakao A, Torihara H, Chakraborty A, Inoue K, Kenmochi N.

Ribosomal protein gene knockdown causes developmental defects in zebrafish.

PLoS ONE 1(1): e37. 2006

剣持直哉

イントロンの進化

生体の科学:生物進化の分子マップ, 57: 347-349. 2006

Nguyen HD, Yoshihama M, Kenmochi N.

Phase distribution of spliceosomal introns: implications for intron origin.

BMC Evol. Biol. 6: 69. 2006  

剣持直哉

ゲノム情報に基づくsnoRNAの解析:ゼブラフィッシュを用いたアプローチ

機能性Non-coding RNA. 83-98. 2006

Yoshihama M, Nakao A, Nguyen HD, Kenmochi N.

Analysis of ribosomal protein gene structures: implications for intron evolution.

PLoS Genet. 2(3): e25. 2006

Ishii K, Washio T, Uechi T, Yoshihama M, Kenmochi N, Tomita M.

Characteristics and clustering of human ribosomal protein genes.

BMC Genomics. 7(1): 37. 2006

Maeda N, Toku S, Kenmochi N, Tanaka T.

A novel nucleolar protein interacts with ribosomal protein S19.

Biochem Biophys Res Commun. 339(1): 41-46. 2006

Nguyen HD, Yoshihama M, Kenmochi N.

New maximum likelihood estimators for eukaryotic intron evolution.

PLoS Comput Biol. 1(7): e79. 2005

Nakao A, Yoshihama M, Kenmochi N.

RPG: the Ribosomal Protein Gene database.

Nucleic Acids Res. 32(Database issue): D168-170. 2004

剣持直哉

リボソームと疾患

実験医学 増刊, 22: 200-205. 2004

Kenmochi N.

Ribosomes and Ribosomal Proteins.

In:Cooper DN (ed.) Nature Encyclopedia of the Human Genome.

Nature Publishing Group, London, 5: 77-82. 2003

剣持直哉

リボソーム病:新たな疾患としての可能性を探る

蛋白質核酸酵素 増刊号, 48: 508-516. 2003

Uechi T, Maeda N, Tanaka T, Kenmochi N.

Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.

Nucleic Acids Res. 30(24): 5369-5375. 2002

Higa S, Maeda N, Kenmochi N, Tanaka T.

Location of 2(')-O-methyl nucleotides in 26S rRNA and methylation guide snoRNAs in Caenorhabditis elegans.

Biochem Biophys Res Commun. 297(5): 1344-1349. 2002

Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N.

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

Genome Res. 12(3): 379-390. 2002

Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T.

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

Genomics. 77(1-2): 65-70. 2001

Uechi T, Tanaka T, Kenmochi N.

A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.

Genomics. 72(3): 223-230. 2001

Ion A, Crosby AH, Kremer H, Kenmochi N, Van Reen M, Fenske C, Van Der Burgt I, Brunner HG, Montgomery K, Kucherlapati RS, Patton MA, Page C, Mariman E, Jeffery S.

Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6.

J Med Genet. 37(11): 884-886. 2000

Kenmochi N, Yoshihama M, Higa S, Tanaka T.

The human ribosomal protein L6 gene in a critical region for Noonan syndrome.

J Hum Genet. 45(5): 290-293. 2000

剣持直哉

リボソームの分子解剖:超分子システムの遺伝子解析

バイオサイエンスとインダストリー. 58: 27-30. 2000

Higa S, Yoshihama M, Tanaka T, Kenmochi N.

Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome.

Gene. 240(2): 371-377. 1999

Kenmochi N.

Ribosomal abnormalities and human diseases.

Seikagaku. 71(3): 205-210. Review. 1999

Kenmochi N, Ashworth LK, Lennon G, Higa S, Tanaka T.

High-resolution mapping of ribosomal protein genes to human chromosome 19.

DNA Res. 5(4): 229-233. 1998

Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC.

A map of 75 human ribosomal protein genes.

Genome Res. 8(5): 509-523. 1998

Kenmochi N, Higa S, Yoshihama M, Tanaka T.

U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.

Biochem Biophys Res Commun. 228(2): 371-374. 1996